APOBEC3B and AID Have Similar Nuclear Import Mechanisms
نویسندگان
چکیده
منابع مشابه
Nuclear Import Mechanisms of STAT and NF-κB Transcription Factors
The eukaryotic cell nucleoplasm is separated from the cytoplasm by the nuclear envelope. This compartmentation of eukaryotic cells requires that all nuclear proteins must be transported from the cytoplasm into the nucleus. Transport of macromolecules between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs), large protein complexes that penetrate and fuse the nuclear en...
متن کاملMechanisms and Signals for the Nuclear Import of Proteins
In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through highly specialized structures known as nuclear pores, and involves the participation of a special class of transport proteins. Active transport across the nuclear pores is an energy-dependent process that relies on the a...
متن کاملIn vitro nuclear import
T he nuclear pore serves as the gateway to the nucleus, allowing molecules to slip in and out. A technique devised by Larry Gerace (Scripps Research Institute in La Jolla, California) and colleagues helped researchers ferret out the biochemical details of nuclear import and export, identifying the driving force as the protein Ran. The same system helped scientists pinpoint the proteins that fer...
متن کاملNuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
Reversible phosphorylation of nuclear proteins is required for both DNA replication and entry into mitosis. Consequently, most cyclin-dependent kinase (Cdk)/cyclin complexes are localized to the nucleus when active. Although our understanding of nuclear transport processes has been greatly enhanced by the recent identification of nuclear targeting sequences and soluble nuclear import factors wi...
متن کاملFunctionally similar species have similar dynamics
1. Improving the mechanistic basis of biodiversity–ecosystem function relationships requires a better understanding of how functional traits drive the dynamics of populations. For example, environmental disturbances or grazing may increase synchronization of functionally similar species, whereas functionally different species may show independent dynamics, because of different responses to the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2012
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2012.03.011